In regard to CASP4/5, a mediator of non-canonical inflammasome activation via NLRP3 (Mazgaeen and Gurung 2020), our results showed a significant decrease of CASP4 peripheral expression in both groups of BD patients (BD-Lithium and BD-OD) compared to healthy controls. This evidence concerns the gene NLRP3 and osteochondritis dissecans.