The NLRP3 activation was previously described in MDD and BD patients (Alcocer-Gómez et al. 2014, 2017; Kim et al. 2016; Scaini et al. 2018; Taene et al. 2020), as well as in the animal models of depression (Pan et al. 2014; Wong et al. 2016; Sahin Ozkartal et al. 2019). This evidence concerns the gene NLRP3 and depressive symptom measurement.