EIF4A3 and acute myeloid leukemia: Moreover, treatment with an eIF4A3 chemical inhibitor (eIF4A3i, with over 100-fold specificity compared to other eIF4A members or helicases [12, 13]) induced cell death in three different p53wt-carrying AML cell line models (Fig. 2A), a phenotype that could be recapitulated when eIF4A3 was silenced with siRNA (Fig. 2B).