EIF4A3 and acute myeloid leukemia: To explore cellular pathways related to eIF4A3 expression, we then performed a differential expression (DE) analysis and found that 1928 genes were up- and 1531 downregulated (Supplementary Table S1B, C) in the AML subset expressing Low eIF4A3 levels compared with High-expressors (identified in Fig. 1D).