EIF4A3 and acute myeloid leukemia: Focusing on AML, we showed that siRNA-mediated eIF4A3 knock-down induces p53 in an IRBC-mediated fashion since concomitant silencing of RPL5 (a component of the 5S-RNP complex that regulates the IRBC [14]) rescued the effect of eIF4A3 KD on p53 (Fig. 2D).