Multivariate analysis was performed using Cox’s proportional hazard method, and included tumour size, tumour grade, tumour stage, NPI, ER status, PgR status, HER2 status and vascular invasion, both nuclear DARPP-32 Thr-34 phosphorylation remained associated with patient survival in these models (HR = 0.658, 95% CI = 0.443–0.978, P = 0.038), but not for cytoplasmic DARPP-32 Thr-34 phosphorylation (HR = 0.763. Here, PPP1R1B is linked to neoplasm.