Multivariate analysis was performed using Cox’s proportional hazard method, and included tumour size, tumour grade, tumour stage, NPI, ER status, PgR status, HER2 status and vascular invasion, both nuclear GRB7 and cytoplasmic GRB7 expression was not associated with patient survival in these models (HR = 0.953, 95% CI = 0.617–1.472, P = 0.828, and HR = 1.090. This evidence concerns the gene GRB7 and neoplasm.