Specifically, we aimed to:Determine if the previously described sLDR-induced protein expression lowering effect on CP13 (pTau) could also occur for other Tau proteins more characteristically linked to AD pathomechanisms such as hyperphosphorylated-tau (pTau; AT8), three-repeat tau (3R-tau) and four-repeat tau (4R-tau). This evidence concerns the gene MAPT and Alzheimer disease.