In contrast, the SPP1+ state is positively correlated with the proportion of Treg, SLEC and NKT cell, and negatively correlated with the proportion of Tn/Tm, Teff/Tem, NK cell and cycling T cells, consistent with a role for SPP1+ macrophages, and Osteopontin itself, in tumor immunosuppression. Here, SPP1 is linked to neoplasm.