In recent years, aptamer-based sensors, or aptasensors, have also gained prominence for the detection of cancer biomarkers (e.g., human epidermal growth factor receptor-2 [HER2])39,40, cardiovascular disease (e.g., C-reactive protein [CRP])41,42, neurological disease (amyloid β)43,44, and infectious disease45,46. This evidence concerns the gene ERBB2 and cancer.