FANCG NM_004629.2:c.1182_1192delinsC p.(Glu395TrpfsTer5), NTHL1 NM_002528.7:c.244C > T p.(Gln82Ter) (also known as NM_002528.6:c.268C > T p.(Gln90Ter) in reference to the previous transcript version), and ERCC6L2 NM_020207.7:c.1424del p.(Ile475ThrfsTer36) (previously denoted as NM_020207.5:c.1457del p.(Ile486ThrfsTer36)) have been identified to cause recessive hereditary diseases with increased risk of cancer6,9,20–23. This evidence concerns the gene ERCC6L2 and hereditary disease.