Besides BC, homozygous NTHL1 c.244C>T significantly associated with a high risk of CRC (OR = 168 [24.4–1152], P = 1.9 × 10–7) and basal-cell skin cancer (OR = 66.0 [6.02–723], P = 6.0 × 10–4) (Table 3). The gene discussed is NTHL1; the disease is skin basal cell carcinoma.