Then, we tested the association of cell-type-specific ADPRSs with seven AD endophenotypes in ROSMAP: autopsy-confirmed AD dementia, immunohistochemistry (IHC)-assessed Aβ and paired helical filament tau (PHFtau), Bielschowsky silver stain-assessed diffuse plaque (DP), neuritic plaque (NP), and neurofibrillary tangle (NFT), and longitudinally assessed cognitive decline (Supplementary Table 2). The gene discussed is MAPT; the disease is Alzheimer disease.