First, individuals affected by CKD or ESKD with APOL1 G1/G2 or G2/2 high-risk genotypes but with the p.N264K missense variant are unlikely to have APOL1-associated FSGS, and therefore an additional cause (immune, toxic, structural, or others) should be investigated because this will likely result in a different therapeutic approach. The gene discussed is APOL1; the disease is chronic kidney disease.