Finally, to test the generalizability of these findings to milder forms of APOL1-associated kidney disease, we investigated the protective effect of the APOL1 p.N264K in individuals from the REasons for Geographic and Racial Differences in Stroke (REGARDS)17 and Electronic Medical Records and Genomics Phase III (eMERGE-III)18 studies. Here, APOL1 is linked to stroke disorder.