The severity of ALI was assessed using a semiquantitative histopathology score system (Table S3), and remarkably, R/WT and R/R mice demonstrated more severe ALI than WT controls, with R/R mice experiencing the most severe ALI, underscoring the critical role of RBM47-ISGylation in the lung (Fig. 2A, Right panel). The gene discussed is RBM47; the disease is acute respiratory distress syndrome.