TSC22D3 and Carcinoma, Lewis Lung: Although it is currently challenging to isolate sufficient specific immune cells from lung tissue for TSC22D3 expression analysis, we isolated tumors and their adjacent tissues (<0.2 cm from the tumor margin) from the Lewis lung carcinoma xenograft model described above and observed significantly increased TSC22D3 expression in xenografts of R/R mice compared with WT (Fig. S4G).