The correlation matrix of the concentration of clinical serum markers including prothrombin time (PT), D-dimer, albumin (ALB), globulin (GLB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), total bilirubin (Tbil), direct bilirubin (Dbil) and clinical features including age of patients with CLD suggested that the serum concentration of COLEC10 was positively correlated with serum concentration of D-dimer, shown as Fig. 8C. The gene discussed is GPT; the disease is congenital secretory chloride diarrhea 1.