DDX5 and hepatocellular carcinoma: Since Wnt activation, in addition to ferroptosis escape by sorafenib, also regulates other oncogenic processes, including proliferation, survival, metabolism, immune tolerance, and angiogenesis [33], we propose that DDX5 overexpression in liver tumors could reverse or stall HCC progression [29], a promising therapeutic approach considering the recent success of RNA therapeutics [52, 55].