SPP1 and colorectal cancer: The C1QC+/SPP1+ tumor‐associated macrophage (TAM) dichotomy was first noted in colorectal cancer (CRC) by Lei Zhang et al[29] and it was confirmed by Xiong Li et al that this dichotomy could discriminate cervical cancer patients with different prognoses.[48] Thus, it was feasible to apply this ubiquitous macrophage classification in our study.