TPM1 and hypertrophic cardiomyopathy: TPM1, a circNEB‐peptide interaction protein, highly expressed in muscle tissue, plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction.[20] Mutations in the TPM1 gene cause hypertrophic cardiomyopathy.[21] In this study, co‐IP assay detected that circNEB‐peptide combined with TPM1 protein, which promoted the differentiation of muscle fibers and the expression of MyoD, MyoG, and Myhc muscle differentiation genes.