After QC, removal of self-interactions, and plotting of the pairwise protein interactions across the melanoma risk genes, the level-zero graph was composed of 1 main graph defining a dense, interconnected network containing the majority of the melanoma risk proteins and 4 independent units describing pairwise connections (NDUFB3:NDUFB9; GGT7:POMT1; REEP4:LEMD1; PPIAL4G:FAT4) (Fig. 4, Supplementary Table 6). This evidence concerns the gene REEP4 and melanoma.