However, the relationship of LCN2 and tumorigenesis still lacks consistent findings, some other reports failed to reveal high LCN2 expression in lymph node metastases,47 and elevated levels of LCN2 can also suppress hepatocellular carcinoma cell proliferation and invasion via the interrupting of JNK and PI3K/Akt signaling pathways.48 The gene discussed is LCN2; the disease is hepatocellular carcinoma.