Considering patients without COVID-19, lobar hemorrhages are often associated with structural changes such as cerebral amyloid angiopathy, arteriovenous malformations or brain tumors.59Independent associated risk factors were anticoagulation, a prior history of IS and APOE e2 or e4 genotype, which had a specific association with lobar ICH.60 This evidence concerns the gene APOE and cerebral amyloid angiopathy.