Patients with hypertension normally have low ACE2 expression, which is further reinforced with SARS-CoV-2 infection, increasing the risk of stroke.75The intrinsic relationship between systolic BP variability and poor prognosis of cerebral hemorrhage should be pointed out, as a high variation in BP during the first 24 hours of admission was associated with an unfavorable hospital prognosis in patients with ICH. The gene discussed is ACE2; the disease is hypertensive disorder.