In addition to the association with lobar ICH and ApoE e4e4 allele, recent findings suggest an increased risk of severe COVID-19 infection in this population, independent of preexisting dementia, hypertension, and DM2.61, 62APOE ε4 carriers also present an increased susceptibility to SARS-CoV-2 infection with higher serum indicators of inflammation.63 The gene discussed is APOE; the disease is hypertensive disorder.