In this RCT among participants with T2D and overweight/obesity, GCE supplementation with doses of 800 mg/d for 10 weeks led to a significant decrease in weight, BMI, SBP, HOMA-IR, serum TG, and CRP levels, and a significant increase in serum HDL levels. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.