So as to test both the neuroprotective and hematopoietic activity following chronic administration of a BBB-penetrating IgG-EPO fusion, mice with experimental PD were treated with a mouse-specific TfRMAb-EPO fusion protein, where the TfRMAb domain is a rat/mouse chimeric antibody derived from the 8D3 antibody against the mouse TfR, as described in the next section. Here, EPO is linked to Parkinson disease.