EPO and Parkinson disease: In a failed clinical trial of systemic EPO in PD, patients were treated by IV infusion of 40,000 IU of EPO, which is about 500 IU/kg; the EPO was administered twice-weekly for 5 weeks, but this treatment had no effect on the Unified Parkinson’s Disease Rating Scale (UPDRS)-III (Jang et al., 2014).