To assess potential differences in locomotion and anxiety-like behaviors in the different groups of mice, we compared total distance travelled (Figure 3A), average speed (Figure 3B), time spent immobile (time freezing) (Figure 3C), and time spent around the outer walls zone (Figure 3D) or in the inner zone of the arena (Figure 3E) between WT + C, C3 KO + C, WT + SE and C3 KO + SE mice. Here, C3 is linked to Anxiety.