We found a significant reduction in overall ADAR1 gene expression in AD patients compared to healthy young adults (Figure 4A), and although there was only a trend for lower ADAR1 gene expression in older compared to younger adults, we did find an increase in TE transcript expression in the brains of these same subjects that was exacerbated in AD vs. healthy older adult brains (Figure 4B). This evidence concerns the gene ADAR and Alzheimer disease.