ADAR and Alzheimer disease: Finally, in support of the idea that these events may contribute to neuroinflammation in vivo, among the most increased TE transcripts in AD vs. healthy older adults and older vs. younger adults, we found 22 TE transcripts that were also identified as ADAR1 targets (TE transcripts with high number of Δ-edits) in our in vitro analyses (Figure 4D).