These findings may be particularly important, as we and others have shown that TE transcripts increase with aging and AD (Guo et al., 2018; LaRocca et al., 2020; Wahl et al., 2023) which, in combination with reduced ADAR1 activity, would support the accumulation of TE-derived dsRNA (Kassiotis and Stoye, 2016; Chen and Hur, 2022). This evidence concerns the gene ADAR and Alzheimer disease.