While some studies have already been focused on the evaluation of the expression profile of IL-33 in hepatic disease during schistosomiasis [15], hepatitis, malaria [16], HIV infected patients [17] and others on tuberculosis [18], very few studies have been carried out on the expression of IL-33 in HIV/TB coinfection compared to each of the mono infections [19-20]. The gene discussed is IL33; the disease is malaria.