As the soluble B7-H6 in N208Q cells increased dramatically, and it was reported that sB7-H6 could be generated by MMPs shedding in different cancer cell lines (36), we hypothesized that the N208 glycosylation protects B7-H6 protein from exposure to certain MMPs and further maintains the membrane bound condition for NK cell recognition. Here, NCR3LG1 is linked to cancer.