In several experimental tumor resection models, when surgical inflammatory response is blocked pre-operatively, but not post-operatively, with either ketorolac (preferentially inhibits COX-1, and therefore not seen by other NSAIDs) or supplementing SPMs, one could completely abrogate the appearance of micro-metastases or dormancy escape, resulting in long-term survival (34). The gene discussed is PTGS1; the disease is neoplasm.