AXIN2 and familial pancreatic carcinoma: In this study, we obtained miR-1275, a differential miRNA associated with NK cell scoring from healthy volunteers and pancreatic cancer patients via bioinformatics analysis and experimental validation., The present study demonstrated the mechanism by which hypoxia inhibited miR-1275 expression in NK cells and promoted AXIN2 expression, which in turn inhibited cancer cell killing ability of NK cells.