In the present work, we use scRNA-seq technology to depict the landscape and temporal revolution of immune microenvironment on the matched bone marrow (BM) and peripheral blood (PB) samples, which were obtained from three MM patients underwent anti-BCMA CAR-T therapy before infusion and at 3, 6 and 9 months post infusion. This evidence concerns the gene TNFRSF17 and Miyoshi myopathy.