PFKFB3 and renal fibrosis: To investigate the role of myeloid glycolysis in renal fibrosis, we utilized a model of unilateral ureteral obstruction in mice deficient of Pfkfb3, an activator of glycolysis, in myeloid cells (Pfkfb3ΔMφ) and their wild type littermates (Pfkfb3WT).