SCG2 and systemic lupus erythematosus: In the validation set GSE7305, CXCL12, ROBO3, and SCG2 were significantly enriched in immune-related pathways, including cytokine-cytokine receptor interaction, chemokine signaling pathway, leukocyte transendothelial migration, systemic lupus erythematosus, and MAPK signaling pathway (Supplementary Figures 2D–F).