Accumulation of TAMs in tumor hypoxic regions and their adaptability to the low-oxygen microenvironment is particularly fascinating as they over-express pro-angiogenic factors (VEGF, pFGF, and CXCL8) and glycolytic enzymes, regulated by hypoxia-induced transcription factors HIF1 and HIF2 (109). This evidence concerns the gene VEGFA and neoplasm.