All three types of small EV subpopulations exhibited a higher median count [CD9+CD14+ small EVs (Figure 4A), CD9+CD61+ small EVs (Figure 4B), and double-positive CD9+CD14+CD61+ small EVs (Figure 4C)] and were capable of distinguishing patients with polytrauma organ damage (OD) from patients without polytrauma (polytrauma without OD). The gene discussed is ITGB3; the disease is osteochondritis dissecans.