LGI1 and acrodermatitis enteropathica: To test the hypothesis that, LGI1-antibodies may lead to increased seizure susceptibility in-vivo, we developed an antibody-mediated AE rat model for LGI-1gG; in which either anti-LGI1 or NMDAR auto-Ab containing total IgG obtained from blood samples of AE patients were passively transferred into the rat brain.