To determine whether patient-derived LGI1-IgG have a pathogenic role in epileptogenesis, we developed a passive transfer rat model in which we infused either pooled anti-LGI1 positive IgG (LGI1-IgG group, n=9) or pooled anti-NMDAR positive IgG (NMDAR-IgG group, n=8) containing total IgG obtained from blood samples of AE patients into the rat brain (Figure 1). Here, LGI1 is linked to acrodermatitis enteropathica.