In addition to poly(dA:dT), LPS plus nigericin also triggered higher IL-18 production in patients, indicating that other signals acting through NLRP3, such as S100A8/A9 (52), could contribute to NLRP3 inflammasome activation in vivo, as recently shown in monocytes from CMML patients (53). Here, IL18 is linked to chronic myelomonocytic leukemia.