Notably, in a model of dextran sodium sulfate (DSS)-induced colitis, the protective effects of olsalazine on disease progression and its inhibitory effect on TNFα mRNA expression, as well as the NF-κB and JAK-STAT3 pathways, are significantly reduced in mice with GPR35 knockout, thus suggesting a critical role of GPR35 in these anti-inflammatory actions (70). The gene discussed is TNF; the disease is colitis.