THBD and agammaglobulinemia: Thus, while in the former GS patient group immune alterations were restricted to reduced serum Ig levels and lack of detectable B-cells, those patients who presented with a delayed onset of hypogammaglobulinemia specifically displayed reduced counts of CM TCD4+ cells (including TFH, Th1, Th2, Th22 and Th1/Th17 cells), total TFH, total Th2, CM TCD8+ cells and both total DC, and their CD1c+ myDC and CD141+ myDCs subsets.