A similar pattern of immune cell alterations was found in a subgroup of age-matched CVID patients (vs. healthy donors), including statistically significantly decreased serum IgG, IgA and IgM levels, and reduced counts of B-cells, total lymphocytes, total CD4+ T-cells, NK-cells and eosinophils, in association with a tendency towards higher TCRγδ+ T-cell counts (p=0.07) and monocytopenia (p=0.051) (Figure 1). This evidence concerns the gene CD4 and common variable immunodeficiency.