In turn, a wider defect in the memory CD4+ T-cell maturation compartment was observed in GS, as compared to CVID patients (41, 42), which involved not only the (reduced) Th2, Th17 and Treg cells, but also the CM/TM, Th22, Th1/Th2, Th1/Th17 and TFH cells, whose counts were found to be also significantly reduced in blood of GS (vs. age-matched healthy donors) but not of CVID patients (42, 44, 45, 60, 61). The gene discussed is CD4; the disease is common variable immunodeficiency.