Thus, compared to patients with a simultaneous diagnosis of thymoma and hypogammaglobulinemia, GS cases with an asynchronous diagnosis of both disease conditions, showed statistically significantly lower counts of total T-cells, TCRαβ+ T-cells, total CM TCD4+ cells and CM TFH, Th1, Th2, Th22 and Th1/Th17 CD4+ T-cells, total TFH CD4+ T-cells, Th2 CD4+ T-cells, CM CD8+ T-cells, total DCs and both CD1c+ myDC and CD141+ myDC (p=0.03). The gene discussed is CD4; the disease is thymoma.