C6orf105 is an androgen-dependent TFPI regulatory protein that enhances the activity of tissue factor pathway inhibitor (TFPI), which cannot counteract tissue factor TF in broncho alveolar lavage (BAL) of patients with advanced IPF, leaving the lungs of IPF patients in a hypercoagulable state (54, 55). This evidence concerns the gene TFPI and idiopathic pulmonary fibrosis.