Patients in clusterA were mainly correlated to MYC targets V1, protein fascinators, ribosome, RNA degradation, spliceosome, RHOBTB2 GTPase Cycle, regulation of pyruvate dehydrogenase (PDH) complex, cluster B was significantly enriched in FGFR1 ligand binding and activation pathways, SHC-mediated cascade: FGFR1, NF-kB is activated and signals survival, termination of O-glycan biosynthesis, Notch signaling pathway, VEGF signaling pathway, non-small cell lung cancer, ether lipid metabolism and Wnt/β-Catenin signaling. Here, RHOBTB2 is linked to non-small cell lung carcinoma.