Univariate COX analysis was performed on 178 differential genes (DEGs), and 12 differential genes (Cu-DEGs) with significant correlation (p. value < 0.05) with prognosis in IPF patients were screened (Supplementary Table 1), IL8RA, DDIT4L, LIG4 as poor prognosis genes, C6orf105, TRERF1 C8orf15, ANK3, MBNL1, LYRM7, AKAP9, NPCDR1, and CENPK were associated with prognostic protection in IPF (Figure 5A). Here, AKAP9 is linked to idiopathic pulmonary fibrosis.