POMC and Autoimmunity: Based on previous cases, paraneoplastic autoimmune ACTH deficiency has been shown to include the following two forms: paraneoplastic spontaneously acquired IAD and paraneoplastic ICI-related hypophysitis (15); however, the number of cases is still limited, and therefore, the details of these autoimmune antibodies as potential disease markers (e.g., anti-POMC antibody) remain unclear.