In this study, we further developed six DRGs (SHCBP, TMEM45A, PIGR, IGLV6-57, TCN1, GFRA1) to construct RS to predict the prognosis of BC patients and used TCGA, GEO separated and TCGA and GEO joint databases to evaluate the prognostic value of RS through a survival curve, RS map, survival state map, and heatmap. Here, GFRA1 is linked to breast cancer.