KRAS and neoplasm: In the investigation involving K-Ras G12D spontaneous lung cancer model mice and Lewis lung cancer mice, the intervention of Shuangshen Granule (a combination of Panax quinquefolius L, Cordyceps sinensis, and Panax notoginseng) resulted in a notable reduction in subcutaneous tumor volume and a remarkable decrease in the proportion of F4/80+CD206+ tumor-associated macrophages (TAMs) (40).