Although evidence from RA is still scarce, data from Mmp28−/− mice shows that macrophages can migrate faster and release more macrophage inflammatory protein such as MIP-1α and MIP-1β, as well as elevated MMP9(79), which suggesting the important role of MMP28 in reducing cell migration and preserving tissue homeostasis in inflammatory disease. Here, MMP28 is linked to rheumatoid arthritis.