In all of the summary of product characteristics (SmPCs) of the studied biologicals, it is recognized that IgE and eosinophils are involved in the immunological response for parasitic infections, hence some caution should be considered when individuals at high risk of parasitic infection are treated with the discussed biologicals (European Medicines Agency, 2015; European Medicines Agency, 2020; European Medicines Agency, 2021; European Medicines Agency 2022b; European Medicines Agency 2022a). This evidence concerns the gene IGHE and parasitic infectious disease.