However, there are some limitations of current approved HDAC inhibitors, such as pan-inhibition, etc. Thus, it is in urgent need to develop novel HDAC inhibitors to improve colon cancer treatment (Place et al., 2005; Sang et al., 2023) Nan Sun et al. designed and synthesized a series of triazole-containing compounds as novel HDAC inhibitors, which have significant anti-proliferation effect on murine and human colon cancer cell lines MC38 and HCT116 (Sun et al., 2023). This evidence concerns the gene HDAC9 and colonic neoplasm.