Meanwhile, VNS suppresses the sympathetic nerve sprouting and blocks the inflammatory process, which attenuating ventricular remodeling and decreases the incidence of ventricular arrhythmias after reperfusion injury on mechanism, Jak2/STAT3, NF-κB, Akt/GSK-3β signaling pathway, which are responsible for VNS induced preventive effects on myocardium during reperfusion injury (Buchholz et al., 2015; Zhao et al., 2021). The gene discussed is JAK2; the disease is Ventricular arrhythmia.