CES2 and metabolic dysfunction-associated steatotic liver disease: For example, the p62/nuclear factor erythroid 2-related factor 2 (NRF2)/carboxylesterase 2 (CES2) and p62/NRF2/PPARα signaling axes are restored by bicyclol, which enhances lipolysis and β-oxidation, while BBR reduces de novo lipogenesis by suppressing ACC and FAS expression; the combination of the two drugs has already been demonstrated to enhance their overall therapeutic effect in improving NAFLD (Li et al., 2022a).