G6PC1 and metabolic dysfunction-associated steatotic liver disease: Berberrubine, a main BBR metabolite, alleviates NAFLD by reducing CD36 expression Moreover, berberine maintains glucose homeostasis in HFD-fed mice by upregulating glucose transporter 2 (GLUT-2) and glycogen synthase kinase 3β (GSK3β) protein expression and inhibiting glucose 6 phosphatase (G6Pase) protein expression (Yang et al., 2022c).