RYR2 and congestive heart failure: Francia et al. (2015) demonstrated that the variant allele increased susceptibility to ventricular tachycardia and ventricular fibrillation in patients with heart failure (HR: 3.49; 95% CI: 1.14–10.62). A Chinese cohort study of 1,244 patients with chronic heart failure indicated that the variant allele of rs3766871 in RYR2 was an independent risk factor that increased the risk of cardiac death (HR: 1.92; 95% CI: 1.24–2.94) and ventricular arrhythmias (OR: 1.66; 95% CI: 1.21–2.26) (Ran et al., 2010).