ESR1 and astrocytoma (excluding glioblastoma): Chen et al. (2019) observed that the A allele of RYR2 rs12594 was associated with overall survival of patients with astrocytoma, demonstrating the impact of RYR2 on the prognosis of lower-grade brain gliomas. Another case-control study showed a relationship between rs12594 polymorphism and the risk of breast cancer in a Chinese population. The RYR2 rs12594GG genotype was related to decreased breast cancer risk even after being adjusted by age, estrogen receptor status, progesterone receptor status, menopausal status, tumor size, and tumor stage (Wei et al., 2020).