RYR2 gene (on 1q42.1-43) encodes the cardiac Ca2+ channel, and mutations have been linked to catecholaminergic polymorphic ventricular tachycardia (CPVT) and SCD (Napolitano and Priori, 2007; Steinberg et al., 2023). This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.