Among three isoforms that encode RyR genes (RYR), RYR2 is expressed predominantly in cardiac muscle (Avila et al., 2019), and it has been reported to be associated with cardiac diseases such as arrhythmias and sudden cardiac death (SCD) (Napolitano and Priori, 2007; Steinberg et al., 2023). The gene discussed is RYR1; the disease is sudden cardiac arrest.