RYR2 and rhabdomyolysis-myalgia syndrome: Three RYR genes have been identified: RYR1, RYR2, and RYR3. The RYR1 gene (on human chromosome 19q13.1), which is responsible for Ca2+ release in skeletal muscle, has been associated with disorders such as King-Denborough syndrome, rhabdomyolysis-myalgia syndrome, and bleeding abnormalities (Dowling et al., 2011; Lopez et al., 2016; Witting et al., 2018).