The best cut-off value of serum MMP-7 in the diagnosis of BA was 25.9 ng/ml, achieving the area under the ROC curve (AUC) of 0.962 (95% CI: 0.941, 0.983), and the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 86.9%, 94.5%, 97.3% and 75.8%, respectively. This evidence concerns the gene MMP7 and breast angiosarcoma.