Network pharmacology analysis demonstrated that significant amount of “drug-disease” common targets were involved in PI3K-AKT pathway; phenylacetic acid, dodec-9-ynyl ester and 2-Pyrazoline-3-carboxylic acid, 5-hydroxy-1-(4-methylbenzoyl)-5-phenyl-, methyl ester from LEO directly interacted with AKT1 and PIK3CA; western blotting results further confirmed the decrease in AKT1 level and increase in PIK3CA level after treatment with LEO in both breast cancer cell lines. Here, AKT1 is linked to breast carcinoma.