The KEGG enrichment analysis identified 165 signaling pathways and revealed that 213 predictive targets were predominantly associated with phosphoinositide 3-kinase-protein kinase B (PI3K-AKT) signaling pathway, proteoglycans in cancer, the Ras signaling pathway, the calcium signaling pathway, chemical carcinogenesis receptor activation, lipid and atherosclerosis, apoptosis and other signal pathways (Fig. 4B). Here, PIK3CA is linked to atherosclerosis.