Besides high activity of the NF-κB pathway, our signalling analysis showed engagement of the EBV pathway in BALF MΦ from patients with severe COVID-19, which is characterized by CD21−, CD19−and MHC-II dependent entry mechanisms, and by a TLR2-MyD88 dependent additional activation of NF-κB [75]. The gene discussed is MYD88; the disease is COVID-19.