These data revealed that besides low levels of type I and III IFNs, elevated chemokines and cytokines, such as IL-6, IL-1β, IL-1RA, IL-8 (CXCL8), IL-18, and TNF-α account for disease severity and death in COVID-19, indicating a sepsis-like response upon progression of disease [73]. Here, IL1R1 is linked to COVID-19.