For this reason, we performed a battery of behavioral tests, assessing general motor abilities (open field), anxiety (light–dark test), sociability (male-female social interaction and three-chamber test), and cognitive abilities (contextual fear conditioning), in 3-month-old REST floxed mice previously injected with either PHP.eB CaMKII-NLS-GFP-Cre or with PHP.eB CaMKII-NLS-GFP-ΔCre as a transduction control (Figure 2A). This evidence concerns the gene CAMK2G and Anxiety.