By exploiting the above-described experimental procedure, we characterized some behavioral traits associated with epilepsy and cognitive disorders in which REST is involved, such as Rett syndrome (Abuhatzira et al., 2007; Tang et al., 2016), X-linked intellectual disability (Tahiliani et al., 2007), and autism (Katayama et al., 2016). This evidence concerns the gene REST and X-linked intellectual disability.