Lung cancer develops via the activating mutations of driver genes, which include the epidermal growth factor receptor (EGFR), anaplastic, lymphoma kinase (ALK), c-ros oncogene 1 (ROS1), v-Raf murine sarcoma viral oncogene homolog, B (BRAF), and (RET) genes (21) with rearrangement at some transfection sites. The gene discussed is ROS1; the disease is lung cancer.