TNF and AIDS: Interleukine-1 hyperproduction is a key point in the pathogenesis of AIDs, and interleukine-1 blockade is a successful treatment for known monogenic AIDs, such as familial Mediterranean fever (FMF), cryopyrin-associated periodic syndrome (CAPS), tumor necrosis factor-associated periodic syndrome (TRAPS), and mevalonate kinase deficiency (MKD) syndrome (2–5).